Collaboration:

Sungkyunkwan University (Korea),

University of West Bohemia in Pilsen (Czech Republic),

Warsaw University of Technology (Poland).

About the project:

The V4 HyFiPatch project focuses on the development of a multifunctional patch made of hydrogel fibers. This innovative product, HyFiPatch, aims to simplify the treatment process for patients with Alzheimer's disease (AD) and thereby reduce patient discomfort. By providing an easily usable solution, the project expects to generate significant commercial value.

Several steps will be taken to achieve the set goals. The first goal is to develop the HyFiPatch patch with anti-inflammatory and antimicrobial functions. This patch will be based on hydrogel polymers, proteins, and bioactive materials that will allow the regulation of antimicrobial substance release. The next step will be the in vitro characterization of HyFiPatch. This will be followed by the in vivo application of the therapeutic HyFiPatch patch for Alzheimer's disease treatment. The development will also involve creating a layered hydrogel patch incorporating a nanofibrous sheet. Additionally, nanoparticle incorporation for reactive oxygen species removal will be conducted to achieve anti-inflammatory properties. The factors influencing drug release from the hydrogel patch will also be investigated. Such a process should lead to the creation of an effective and efficient treatment for Alzheimer's disease.